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Molds or fungi are
a major group of non-motile, eukaryotic organisms that have defined cell walls,
lack chlorophyll and reproduce by means of spores. Everyone knows that molds have been around for millions of years and will
more than likely be around for a few million more. We've all
seen it on bread that hung around a little too long, in our bathrooms where the
grout has blackened between the tiles, and virtually everywhere outside.
The increased efficiency of today's structures affecting indoor air quality,
the types of materials used in construction, poor building and equipment
maintenance, poor ventilation and other factors have created environments
favorable to mold growth. In the past, there was no widely accepted connection between
mold and detrimental health effects.
There is so much emphasis on
making structures airtight to better regulate environmental controls that
buildings are unable to "breathe" anymore, causing increased moisture
problems, if not properly maintained. Heating, ventilation, and
air conditioning (HVAC) equipment that is not
regularly inspected may be home to mold and poor building maintenance invites
unabated mold growth. Most molds found in the home or business located on
non-porous surfaces smaller than 10 square feet can simply be cleaned using an
anti-microbial or a biocide. If active growth is visible on
porous surfaces (e.g. drywall, wood, carpet, upholstery, etc.), professional
mold remediation should be seriously considered. It is important to
regularly inspect the structure for poor drainage, roof leaking, plumbing, and
HVAC systems to prevent any moisture build-up. Any materials that are found to
be wet should be immediately dried within 48 hours. Normally after 48 hours,
certain molds will amplify. If visible
mold and/or musty odors are present, the source of the moisture problem(s)
should be discovered quickly and the mold eliminated, otherwise, the mold
problem will just get bigger.
MOLD GLOSSARY
Acremonium naturally found in soils, decaying organic matter and plat debris. Can be found in food and indoor environments. A common allergen. Can produce a trichothecene mycotoxins and volatile organic compounds.
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Agrocybe/Coprinus This genus is a basidiomycetous mould. Fungal spores which are from mushrooms. The specific mushroom species can not be identified on the culture plate. Many mushroom spores are reorted to be allergenic
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Alternaria A common saprobe found on decaying
wood, decaying plants, food, spoil and outdoor air. Some species are
plant pathogens. Indoors, it can be found in house dust, carpets, damp
areas around showers and windows frames and anywhere condensation occurs.
Because of its abundance and ubiquity, Alternaria is one of the most important
fungal allergens and is recognized as the chief fungal cause of hay
fever. Infection is extremely rare.
Arthrinium is a cosmopolitan filamentous
fungus isolated from plant debris and soil. There are no infections so far
reported due to Arthrinium in humans or animals. Since Arthrinium is
cosmopolitan in nature, it is an occasional laboratory contaminant.
Ascomycete constitute
the largest class of fungi characterized by the production of sexual spores in
structures call asci. This includes plant pathogens, saprobes and
decomposers. With a few exceptions, most Ascomycetes do not grow in
buildings and are seldom agents of wood rot. Ascomycetes are the perfect
stages of molds like Aspergillus and Penicillium. At high levels,
Ascomycete spores may cause allergies.
Since most Ascomycetes are plant pathogens, ascospores are common during the
growing season of plants and are rare during winter, such as those of the
Ascomycetes genera: Daldinia, Hypoxylon, Paraphaeospaeria, Phaeosphaeria and
Leptosphaeria.
Aspergillus Reported to be allergenic. Members of this genus are reported to cause ear infections. Many species produce mycotoxins which may be associated with disease in humans and other animals. Toxin production is dependent on the species or a strain within a species and on the food source for the fungus. Some of these toxins have been found to be carcinogenic in animal species. Several toxins are considered potential human carcinogens. Common cause of extrinsic asthma (immediate-type hypersensitivity: type I). Acute symptoms include edema and bronchiospasms, chronic cases may develop pulmonary emphysema.
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Aureobasidium A Common saprobe frequently
isolated from soil, plant surfaces, seeds, grains, fruits and other food, human
skin and nails. Common indoors in humid areas such as
bathrooms, kitchens, poorly maintained HVAC systems and window frames.
Allergies to Aureobasidium are common, but infections are rarely reported.
Basidiomycetes A
class of fungi characterized by spores formed on basidia. Included the mushrooms, toadstools, wood bracket fungi and puffballs.
Some species are edible, such as Agaricus bisporus, the commercially
cultivated mushrooms. A few species cause wood brown rot, white rot and
dry rot in buildings.
Bipolaris The genus Bipolaris is
cosmopolitan in nature and can be isolated from plant debris and soil. It
contains about 45 species, most of which are subtropical and tropical plant
parasites. However, a few species are capable of causing disease in humans.
Botrytis is a filamentous fungus isolated
from decaying plants. No infections due to Botrytis have been reported in
humans or animals. It may act as a facultative pathogen in plants and is
commonly considered as a contaminant
Cercospora This genus is a mould that lacks a
known sexual state and thus belongs to the Fungi Imperfecti.
Chaetomium A common fungus in soils, dung, decaying organic matter, seeds and wood or other cellulose-containing materials. Can be found indoors in water-damaged buildings on sheet rock, wall paper and other paper products. It is a common cause of food spoilage. In some species it is allergenic, but rarely causes human infections
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Chrysosporium A common soil saprobe
occasionally isolated from human or animal skin and nail. Chrysosporium
inops is xerophilic and occurs in food.
Cladosporium is widely distributed as plant pathogens and saprobes. It is the most frequently found fungus in outdoor air. Indoors, it usually occurs at low concentrations in damp or humid areas, but may be found in high concentrations in water-damaged building materials. Its ability to sporulate heavily and to get airborne makes it an important fungal allergen. Frequently isolated as a contaminant in foods. Only occasionally associated with disease in humans; one species can cause chronic subcutaneous infection.
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Epicoccum A cosmopolitan saprobe isolated
from air, soil, grain, seeds, textiles, paper products and food
materials. Can be a plant pathogen and is a common cause of leaf spots of
various plants. Can be found in indoor environments, where it can grow
under conditions of low humidity. It is a know allergen and is
occasionally isolated from human skin and sputum.
Eurotium Can be
found in stored food, fruit juices, grains, nuts, milled rice, spices, meat
products and peas. Also commonly occurs in indoor environments.
Eurotium harboriorum may case keratitis and indigestion in man.
Exophiala is a dematiaceous fungus widely
distributed in soil, plants, water, and decaying wood material. As well as
being a saprophyte in nature, it is the causative agent of various human
infections.
 Fusarium A common soil fungus. It is found on a wide range of plants. It is often found in humidifiers. Several species in this genus can produce potent trichothecene toxins. The trichothecene (scirpene) toxin targets, the following systems: circulatory, alimentary, skin and nervous. Produces vomitoxin on grains during unusually damp growing conditions. Symptoms may occur either through ingestion of contaminated grains or possibly inhalation of spores. The genera can produce hemorrhagic syndrome in humans (alimentary toxic aleukia). This is characterized by nausea, vomiting, diarrhea, dermatitis, and extensive internal bleeding. Reported to be allergenic. Frequently involved in eye, skin and nail infections
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Ganoderma Large very hard,
woody bracket fungus that grows on living and dead trees. Some species
are common on oaks, chestnuts and conifers such as hemlocks, spruces and pines.
Many species are being investigated for possible medicinal uses
Gliocladium is a mitosporic filamentous
fungus which is widely distributed in soil and decaying vegetation. It is
commonly considered as a contaminant.
Graphium is a filamentous fungus found in
soil and plant material. While Graphium may be isolated as an occasional
contaminant, its telemorphs, Petriella, Pseudallescheria, and Ceratocystis
may cause diseases. Most isolates of Graphium isolated in the clinical
laboratory are synanamorphic forms of Pseudallescheria boydii or
secondary forms with Scedosporium apiospermum.
Mucor is a filamentous fungus found in soil,
plants, decaying fruits and vegetables. As well as being ubiquitous in nature
and a common laboratory contaminant, Mucor spp. may cause infections in man,
frogs, amphibians, cattle, and swine. Most of the Mucor spp. are unable to grow
at 37°C and the strains isolated from human infections are usually one of the
few thermotolerant Mucor spp..
Myxomycete is an ancient form of slime
mold. Not much is presently known about Myxomycete. It is often
found on decaying wood or organic material
Paecilomyces A
common saprobe found on dead plant and compost. Some species are insect
parasites. Can cause food decomposition.
It is rarely a human pathogen, but can cause infection in animals.
However, some species are emerging as causative agents of disease in
immunocompromised individuals.
Penicillium A wide number of organisms have placed in this genera. Identification to species is difficult. Often found in aerosol samples. Commonly found in soil, food, cellulose and grains. It is also found in paint and compost piles. It may cause hypersensitivity pneumonitis, allergic alveolitis in susceptible individuals. It is reported to be allergenic (skin). It is commonly found in carpet, wall paper, and in interior fiberglass duct insulation. Some species can produce mycotoxins. Common cause of extrinsic asthma (immeadiate-type hypersensitivity: type I). Acute symptoms include edema and bronchiospasms, chronic cases may develop pulmonary emphysema.
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Phialophora occurs in nature as a soft rot fungus on wood, which
and often cause a blue stain. Can cause diseases in
immunocompromised individuals.
Phoma A common indoor air allergen. The
species are isolated from soil and associated plants (particularly potatoes).
Produces pink and purple spots on painted walls. It will grow on butter, paint
cement and rubber. It may cause phaeohyphomycosis a systematic or subcutaneous
disease
Pithomyces This genus is a mould that lacks a known sexual state
and thus belongs to the Fungi Imperfecti. It is generally classified as a
dematiaceous (dark-walled) fungus. Grows on dead grass in
pastures. Causes facial eczema in ruminants
Rhizopus Frequently isolated from soil and
agricultural products, such as cereals and vegetables. Can
cause infection in immunocompromised, malnourished or severely burned
individuals.
Rhodotorula A reddish yeast frequently isolated from air, soil, water,
fruit juice, dairy products and other substances. Typically found as a saprobe
in moist environments indoors such as carpeting, cooling coils, water tanks,
humidifiers and drain pipes. Reported to be allergenic.
Has colonized terminally ill patients.
Rust Obligate parasitic fungi, which belong to Tellomycetes –
Uredinales that cause plant disease.
Smut Obligate parasites and pathogens of
plants that cause smut on various plant pars such as Silene anthers, corn
kernels, onion bulbs and rice grains.
Sporobolomyces can be commonly detected in air samples.
Frequently encountered indoors in water tanks, humidifiers, drain pans, etc.
Stachybotrys Several strains of this fungus (S. atra, S. chartarum and S. alternans are synonymous) may produce a trichothecene mycotoxin- Satratoxin H - which is a poisonous by inhalation. The toxins are present on the fungal spores. This is a slow growing fungus on media. It does not compete well with other rapidly growing fungi. The dark colored fungi grows on building material with a high cellulose content and a low nitrogen content. Areas with relative humidities above 55% and are subject to temperature fluctuations are ideal for toxin production.
Individuals with chronic exposure to the toxin produced by this fungus reported cold and flu symptoms, sore throats, diarrhea, headaches, fatigue, dermatitis, intermittent local hair loss and generalized malaise. The toxins produced by this fungus will suppress the immune system affecting the lymphoid tissue and the bone marrow. Animals injected with the toxin from this fungus exhibited the following symptoms, necrosis and hemorrhage within the brain, thymus, spleen, intestine, lung, heart, lymph node, liver, and kidney. Affects by absorption of the toxin in the human lung are known as pneumomycosis.
This organism is rarely found in outdoor samples. It is usually difficult to find in indoor air samples unless it is physically disturbed or if there is (speculation- a drop in the relative humidity). The spores are in a gelatinous mass. Appropriate media for the growth of this organism will have a high cellulose content and a low nitrogen content. The spores will die readily after release. The dead spores are still allergenic and toxigenic. Percutaneous absorption has caused mild symptoms.
There is controversy about toxigenic effects through inhalation of spores or mycelia |
Tetraploa This genus is a mould that lacks a
known sexual state and thus belongs to the Fungi Imperfecti.
Torula A very common hyphomycete on all kinds of dead, decaying
herbaceous stems, especially in humid conditions. It forms dense, olive green
to black areas of "mould", the colour that of the abundant conidia.
It is reported to be allergenic.
Trichoderma Very common especially in soil and decaying wood,
dead leaves, fallen timber, compost heaps and
activated sludge. Can be found indoors in water damaged
buildings. Has occasionally bee associated with disease in
immunocompromised individuals.
Tritirachium A saprobe commonly isolated from decaying plant
materials. Easily gets airborne. Can cause
corneal ulcers.
Ulocladium Found as a saprobe in soil, plant
materials, rotten wood, appear, textiles and cellulose materials. Frequently collected in air and dust samples. Can grow indoors on water damaged building materials.
Has not been associated with disease in humans, but can be very allergenic.
Verticillium is a widely distributed
filamentous fungus that inhabits decaying vegetation and soil. Some Verticillium
species may be pathogenic to arthropods, plants, and other fungi. It is
commonly considered as a contaminant. Verticillium may very rarely cause
human disease.
Wallemia A very xerophilic
fungus that has been isolated from soil, air, hay, textiles and food such as
jam, salted fish and mild products. Can cause
allergies.
Yeast Various yeasts are commonly identified
on air samples. Some yeasts are reported to be
allergenic. They may cause problems if a person has had previous exposure and
developed hypersensitivity's. Yeasts may be allergenic to susceptible
individuals when present in sufficient concentrations.
Molds can be found
almost anywhere; they can grow on virtually any organic substance, as long as
moisture and oxygen are present. There are molds that can grow on wood, paper,
carpet, foods, and insulation. When excessive moisture accumulates in buildings
or on building materials, mold growth will often occur, particularly if the
moisture problem remains undiscovered or unaddressed. It is impossible to
eliminate all mold and mold spores in the indoor
environment. However, mold growth can be controlled indoors by controlling
moisture indoors.
Molds reproduce by making spores that usually cannot be seen without
magnification. Mold spores waft through the indoor and outdoor air continually.
When mold spores land on a damp spot indoors, they may begin growing and
digesting whatever they are growing on in order to survive. Molds gradually
destroy the things they grow on.
Many types of molds exist. All molds have the potential to cause health
effects. Molds can produce allergens that can trigger allergic reactions or
even asthma attacks in people allergic to mold. Others are known to produce
potent toxins and/or irritants. Potential health concerns are an important
reason to prevent mold growth and to remediate/clean up any existing indoor
mold growth.
Allergic Reactions
Inhaling or touching mold or
mold spores may cause allergic reactions in sensitive individuals. Allergic
reactions to mold are common _ these reactions can be immediate or delayed.
Allergic responses include hay fever-type symptoms, such as sneezing, runny
nose, red eyes, and skin rash (dermatitis). Mold spores and fragments can
produce allergic reactions in sensitive individuals regardless of whether the
mold is dead or alive. Repeated or single exposure to mold or mold spores may
cause previously non-sensitive individuals to become sensitive. Repeated
exposure has the potential to increase sensitivity.
Asthma
Molds can trigger asthma attacks in persons
who are allergic (sensitized) to molds. The irritants produced by molds may
also worsen asthma in non-allergic (non-sensitized) people.
Hypersensitivity
Pneumonitis
Hypersensitivity pneumonitis may develop
following either short-term (acute) or long-term (chronic) exposure to molds.
The disease resembles bacterial pneumonia and is uncommon.
Irritant Effects
Mold exposure can cause irritation of the
eyes, skin, nose, throat, and lungs, and sometimes can create a burning
sensation in these areas.
Opportunistic
Infections
People with weakened immune systems (i.e.,
immune-compromised or immune-suppressed individuals) may be more vulnerable to
infections by molds (as well as more vulnerable than healthy persons to mold
toxins). Aspergillus fumigatus, for example, has been known to infect
the lungs of immune-compromised individuals. These individuals inhale the mold
spores which then start growing in their lungs. Trichoderma has also
been known to infect immune-compromised children.
Healthy individuals are usually not
vulnerable to opportunistic infections from airborne mold exposure. However,
molds can cause common skin diseases, such as athlete's foot, as well as other
infections such as yeast infections.
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